Eric Dane, ‘Grey’s Anatomy’ star McSteamy, dies at 53 after ALS battle

Actor Eric Dane, best known for playing Dr Mark Sloan in Grey’s Anatomy, has died at the age of 53, his family confirmed.

The star passed away on Thursday, nearly a year after publicly revealing he had been diagnosed with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS,” his family said in a statement. They added he spent his final days surrounded by close friends, his wife and his two daughters, Billie and Georgia.

From ‘McSteamy’ to major TV roles

Dane rose to global fame as Dr Mark Sloan, nicknamed McSteamy, on Grey’s Anatomy. Introduced in the show’s second season in 2006, the role quickly became a fan favourite and was later expanded into a main cast position.

He remained on the hit medical drama until 2012, when his character was written out.

Beyond Grey’s Anatomy, Dane built a steady television and film career, appearing in HBO’s Euphoria as Cal Jacobs and starring in TNT’s The Last Ship.

His film credits included Valentine’s Day, Burlesque, Marley & Me, American Carnage and Bad Boys: Ride or Die.

Early life and career path

Born in San Francisco in 1972, Dane initially pursued water polo before discovering acting in high school. After moving to Los Angeles with little money, he landed guest roles on series including Saved by the Bell, The Wonder Years, Roseanne and Married… with Children.

He also appeared in two seasons of Charmed before his breakout success on Grey’s Anatomy.

Family and personal life

Dane married actress Rebecca Gayheart in 2004. The couple welcomed daughters Billie and Georgia in 2010 and 2011.

Gayheart filed for divorce in 2018, but moved to dismiss the filing in March 2025.

Dane had previously spoken publicly about struggles with addiction and depression during his career.

Final chapter

Following his ALS diagnosis in 2025, Dane became an advocate for awareness and research into the neurodegenerative disease.

His family said he remained grateful for the support he received from fans throughout his illness.

He is survived by his daughters.